International Medical Journal, Vol. 21., Iss. 1, 2015, P. 35−39.
DYNAMICS OF CYTOKINE STATUS INDICATORS IN PATIENTS WITH ACUTE ULCERATIVE GASTRODUODENAL BLEEDING AT SURGICAL TREATMENT
Azerbaijan Medical University, Republic of Azerbaijan, Baku
V. T. Zaitsev Institute of General and Emergency Surgery of NAMS of Ukraine, Kharkiv, Ukraine
Treatment of patients with severe ulcerative gastroduodenal bleeding is a significant problem of modern gastroenterology. Among the causes of peptic ulcer disease is disorder of the immune state of the organism, in which an important role is played by cytokines. To study the dynamics of the content of cytokines at blood loss of varying degrees caused by acute ulcerative gastroduodenal hemorrhage, the patients were examined preoperatively and on days 3, 7 and 14 after the surgery. The concentration of pro−inflammatory and anti−inflammatory cytokines in the blood was determined by ELISA. All patients had changes in the local and systemic levels of pro− and anti−inflammatory cytokines compared with healthy subjects. The findings of the study allow the conclusion about the imbalance of cytokine state, the severity of which depends on the severity of blood loss, and that surgery against a background of imbalance in basic conservative therapy does not lead to recovery and requires adequate cytokine therapy.
Key words: cytokine status, acute ulcerative gastroduodenal bleeding, blood loss.