International Medical Journal, Vol. 21., Iss. 1, 2015, P. 22−25.
ANTIHYPERTENSIVE THERAPY EFFECTS FROM THE PERSPECTIVE OF EVIDENCE-BASED MEDICINE
Kharkiv National Medical University, Ukraine
Arterial hypertension is one of the commonest cardiovascular risk factor in Ukrainian population. The risk of forming and manifestation of angina, coronary insufficiency, myocardial infarction and sudden death is distinctly and impressively related to the antecedent level of both systolic and diastolic blood pressure. Thus, there is increasing evidence that efforts should be directed to preventing development and progression of arterial hypertension, although debate continues about antihypertensive drugs to be considered the best in different clinical situation. The authors report the data about Pilot Project on Arterial Hypertension in Ukraine during 2012−2014. The information concerning pharmacokinetics and pharmacodynamics of Amplodipine that should be considered on prescription of this medicine is analyzed. Common results about Amlodipine application in definite clinical cases are presented. Thus, at present dihydropiridine calcium channel antagonists with their metabolic neutrality, anti−ischemic and organ−protection properties are one of the most effective classes of antihypertensive medication for primary stroke prevention in arterial hypertension and are recommended as first order antihypertensive drugs in such clinical cases as left ventricular hypertrophy, silent atherosclerosis, angina pectoris, peripheral artery affection, isolated systolic hypertension in elderly patients and those with metabolic syndrome.
Key words: antihypertensive therapy, amlodipine, efficacy, safety, effects.