ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 20., Iss. 4, 2014, P. 45−48.
SIGNIFICANCE OF ANGIOGENIC GROWTH FACTORS IN PROGNOSIS OF FETAL GROWTH RETARDATION SYNDROME DEVELOPMENT
Kharkiv National Medical University, Ukraine
City Specialized Maternity Hospital № 5, Kyiv, Ukraine
The concentration of vascular endothelial growth factor (VEGF), placenta growth factor (PGF) and their soluble receptor (VEGF−R1) were investigated in the blood serum in the dynamics of physiological pregnancy and intrauterine growth retardation syndrome (IGRS). It was revealed that in women with uncomplicated pregnancy, increase of VEGF concentration decreased with the term of gestation that confirmed preserved compensation capabilities of the fetoplacental system. The level of PGF at the physiological course of gestational process was characterized by rapid growth of concentration by the end of the second trimester and smooth decline in the third trimester, that indicates probability of development of subcompensated placental insufficiency (PI) and high risk of IGRS development. During uncomplicated pregnancy the level of VEGF−R1 remained relatively stable. Along with the change of maintenance of growth factors (GF) the products of their receptors change in the process of gestation development. The changes of VEGF−R1 at pregnancy complicated with IGRS, along with modification of production of corresponding growth factors, increases the possibility of damage of different links in the general chain of angio− and mitogenic effects of PGF and IGRS. Our findings suggest that alteration in the products of GF at IGRS are revealed before the clinical of manifestation of this obstetric complication and can be used as screening markers for diagnosis of fetus growth disorders.
Key words: angiogenic growth factors, fetal growth retardation syndrome, prevention, treatment.