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№4' 2014

INFECTIOUS DISEASES

International Medical Journal, Vol. 20., Iss. 4, 2014, P. 72−74.

CHARACTERISTIC OF CYTOKINE METABOLISM IN PATIENTS WITH HIV/HCV CO-INFECTION

Kharkiv National Medical University, Ukraine

Pandemic of HIV−infection/AIDS is one of global issues of our time and an important problem of global health. The content of cytokines (proinflammatory cytokines, tumors necrosis factor−α (TNF−α), interleukin−1β (IL−1β), interleukin−2 (IL−2), interleukin−6 (IL−6), interleukin−8 (IL−8) and anti−inflammatory interleukin−10 (IL−10)) was determined in serum of 62 patients, of them 32 with HIV infection and 30 with co−infection HIV/HCV. The age of the patients ranged from 20 to 69 years. Comparison group consisted of 32 healthy age and sex matched individuals. According to the study results, macronutrient content was significantly different in patients of the control group and in patients with HIV infection, chronic hepatitis C and HIV/CHC co−infection. HIV−infected patients showed a significant decrease in IL−6, IL−2, IL−1 and an increase in IL−10 and TNF level. Patients co−infected with HIV/HCV demonstrated a significant decrease in IL−6, IL−2 and an increase in IL−10 and TNF. Patients co−infected with HIV/HCV, compared with HIV−infected patients, showed substantial (40 %) restructuring in the production of cytokines, perhaps influenced by the chronic hepatitis C. When comparing the levels of cytokines in the groups of patients, significant differences were noted in the content of IL−1β and IL−10. The content of IL−1β was 2.9 times higher in patients co−infected with HIV/HCV (p < 0.05), and the level of pro−inflammatory cytokine IL−10 was higher 1.4 times (p < 0.001) in HIV−infected patients. In relation to other inflammatory cytokines, a marked tendency to higher values in patients co−infected with HIV/HCV, compared with the group of HIV−infected patients, namely, IL−8, 1.3 times (p < 0.05), IL −2 in 1.1 times (p > 0.05), TNF 1.9 times (p > 0.05), and IL−6 2.7 times (p > 0.05) was noted.

Key words: HIV infection, HIV/HCV co−infection, cytokines, immunity.