International Medical Journal, Vol. 20., Iss. 3, 2014, P. 45−49.
The means of drug correction of homocysteine levels and lipid blood profile in patients with ischemic stroke within early recovery period
Lugansk State Medical University, Ukraine
Lugansk Interregional Centre of Vocational Rehabilitation of Persons with Disabilities, Ukraine
Complex clinical and laboratory investigation of 102 patients was done during the early recovery period of ischemic stroke using clinical neurological and laboratory (determination of lipid profile, blood plasma homocysteine), neuroimaging (MRI) studies and statistical methods. Early recovery period of the disease was noted to correlate with neurological deficiency, persistent violations of lipid spectrum, increased concentration and hyperhomocysteinemia, which supports and enhances dyslipoproteinemia. Great deviations in the investigated laboratory parameters were found in atherothrombotic and cardioembolic ischemic stroke subtypes. Therefore, complex therapy of post−stroke neurological disorders included lipolytic therapy combined with vitamin complex Milgamma administered orally for 20 days along with traditional one. The analysis of the results of treatment demonstrated a positive dynamics in the state in the form of leveling neurological status and normalization of the laboratory parameters. In conclusion, the patients in the early recovery period of ischemic stroke are recommended to control blood lipid levels and plasma homocysteine to predict disease outcome and administer an adequate therapy.
Key words: homocystein, lipid blood profile, ischemic stroke, diagnosis, treatment.