International Medical Journal, Vol. 20., Iss. 2, 2014, P. 46−49.
ULTRASTRUCTURAL CHANGES IN MESOTHELIAL CELL ORGANELLES IN ADHESIVE PERITONEAL DISEASE PATIENTS
Institute of General and Urgent Surgery of AMS of Ukraine, Kharkiv
Kharkiv National Medical University
Adhesive peritoneal disease is an important question of abdominal surgery. 55−70% of the patients develop adhesions, which can cause acute ileus, after abdominal surgery. The questions of prognosis and prevention of adhesions is one of main tasks of surgery, but the criteria of risk of adhesion development are still not clear. The ultrastructure of mesothelial cells of the peritoneum was investigated using the tissue samples taken during the operation for electron microscopy. The study demonstrated the presence of dystrophic, destructive and often degenerative disorders of organelles and intercellular membrane structures. These patients also demonstrated the course of catabolic intracellular processes which are structurally proven by the presence of secondary lysosomes and lipid inclusions in the mesothelial cell cytoplasm. A large number of free ribosomes and polysomic was seen in the cytoplasm of these cells. Thus, the presence of metabolically active mesotheliocytes indicates the action of reserve intracellular repair mechanisms.
Key words: ultrastructure of peritoneal mesothelial cells, adhesive disease of the peritoneum, acute intestinal obstruction.