International Medical Journal, Vol. 20., Iss. 1, 2014, P. 21−29.
ANALYSIS OF GENETIC FACTORS IN PATIENTS WITH CHRONIC HEART FAILURE
1V.I. Razumovsky Saratov State Medical University, Ministry of Health of RF; 2Medical Center Di
This review deals with investigation of polymorphism of genes encoding proteins of the major neurohumoral systems involved in development and progression of chronic heart failure and other heart diseases.. The data on the relationship of polymorphic variants of these genes encoding the proteins of renin−angiotensin−aldosterone and sympathoadrenal systems as well as about polymorphism of genes encoding pre−inflammatory cytokines are featured. The findings of the research proving the association of polymorphic variants of genes encoding angiotensin−converting enzyme, angiotensinogen, angiotensin and beta−adrenerergic receptors with development and the character of course of arterial hypertension, coronary artery disease, chronic heart failure are presented. The data about the association of polymorphic variants of the above genes and efficacy of the administered therapy and incidence of some side effects at administration of angiotensin−converting enzyme inhibitors and beta−adrenoblockers are reported. The problems of practical use of the results of genetic testing, in particular, in prognosis of the reaction in patients with chronic heart failure to the treatment means and prevention according to personalized medicine are analyzed.
Key words: gene, polymorphism, chronic heart failure, angiotensin−converting enzyme.