International Medical Journal, Vol. 19., Iss. 2, 2013, P. 21−24.
STRUCTURAL FEATURES OF VASCULAR ENDOTHELIUM IN ACUTE CEREBRAL ISCHEMIA
Kharkiv Medical Academy of Post−graduate Education, Kharkiv, Ukraine
Abstract. Severe medical social consequences of acute cerebral blood flow disorders are reflected in the indices of the population disability. Therefore, investigation of the pathophysiology of acute cerebral ischemia and development of effective methods of the revealed disorders correction are important. The number of desquamated endotheliocytes was investigated in the venous blood using immunocytochemistry method and monoclonal antibodies CD34 in the course of examination of the patients in acute period of carotid ischemic stroke and patients with transient ischemic attacks in the carotid basin. Vascular endothelium disorganization manifesting as increase of the number of desquamated endotheliocytes in the peripheral blood flow was revealed, which is a promising direction in the diagnosis of cytochemical disorders in these patients, prerequisite for urgent medical aid and prevention of acute cerebral ischemia.
Key words: carotid ischemic stroke, transient ischemic attack, endothelium, desquamated endotheliocytes.