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№2' 2013
GASTROENTEROLOGYInternational Medical Journal, Vol. 19., Iss. 2, 2013, P. 64−68.
THE INFLUENCE OF STANDARD SCHEMES OF ANTI-ULCER THERAPY ON CLINICAL LABORATORY FINDINGS IN PATIENTS WITH DUODENAL ULCER
Tashkent Medical Academy, Tashkent, Republic of Uzbekistan
Abstract. Earlier studies performed by the authors have demonstrated multidirectional effects of the components of second−line quadritherapy on the state of aggressive−protective factors in the gastroduodenal mucosa. The purpose of this work was to investigate two standard schemes of second−line quadritherapy in patients with duodenal ulcer. It was determined that schemes with Omeprazole, De−Nol, amoxicillin, tetracycline and Omeprazole, De−Nol, tetracycline, metronidazole influence equally the dynamics of clinical symptoms and frequency of H. pylori eradication. However, the first scheme more effectively influenced the disorders in the mechanism of synthesis of protective mucus barrier and regeneration processes, which contributed to the high frequency of ulcer cicatrisation.
Key words: ulcer, second−line quadritherapy, cytoprotection, cicatrisation, H. pylori.