International Medical Journal, Vol. 19., Iss. 1, 2013, P. 44−49.
The influence of cardioprotection on the state of hemodyncmics at treatment of cardiorenal syndrome in patients with chronic heart failure and chronic kidney disease
Kharkiv National Medical University; SI Institute of Therapy named by L.T. Malaya NAMS of Ukraine, Kharkiv, Ukraine
Abstract. Cardioprotectors play an important role in treatment of myocardial dysfunction at chronic heart failure (CHF). The purpose of the work was to investigate the influence of quercetin on the parameters of structural functional characteristics of the myocardium, the functional state of the kidneys at treatment of CHF and CHF accompanied with chronic kidney disease (CKD). The parameters were investigated using echocardiography and Doppler echocardiography, the kidney function was determined by Jaffe technique and immunoenzyme assay. Administration of quercetin in patients with CHF and CHF associated with CKD resulted in additional improvement of the markers of kidney dysfunction, immune inflammation, structural and functional parameters of the myocardium. Thus, introduction of quercetin to the standard therapy of these patients was accompanied by additional immunomodulating, cardioprotective and nephroprotective effect, which manifested by improvement of the activity of the heart and kidneys. The findings of the research allow the physicians to improve the therapeutic tactics in patients with CHF and CKD.
Key words: chronic heart failure, chronic kidney disease, systolic function of the myocardium, diasctolic function of the myocardium, kidney dysfunction markers.