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№1' 2013

THERAPY

International Medical Journal, Vol. 19., Iss. 1, 2013, P. 50−52.

Renal dysfunction and peculiarities of iron metabolism in patients with chronic heart failure of various functional classes and chronic kidney disease

Kharkiv National Medical University, Kharkiv, Ukraine

Abstract. Anemia and renal dysfunction are the most common comorbid states at chronic heart failure. The purpose of the work was to assess the functional state of the kidneys and iron metabolism in patients with anemia developing against a background of chronic heart failure of various functional classes and chronic kidney disease. Iron concentration, total serum iron−binding capacity was determined by colorimetry, urine albumin was determined by immunoenzyme assay. It was revealed that reduction of glomerular filtration rate simultaneously with the increase of the functional class of chronic heart failure were accompanied by the signs of iron deficiency due to the loss of iron with urine at microalbuminuria. Increase of renal dysfunction proportional to the severity of heart decompensation negatively influenced the functioning, accessible to erythropoiesis, iron pool, which manifested by reduction of serum iron level and coefficient of transferrin saturation.

Key words: chronic heart failure, chronic kidney disease, anemia, iron metabolism.