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№1' 2013

PEDIATRICS

International Medical Journal, Vol. 19., Iss. 1, 2013, P. 34−38.

The level of post-vaccination antidiphtheria immunity in children depending of the duration of type 1 diabetes mellitus

Kharkiv Medical Academy of Post−graduate Education, Kharkiv, Ukraine

Abstract. The indices of artificial active antitoxic antidiphtheria immunity in children and teen−agers with type 1 diabetes mellitus (DM1) were investigated depending on the disease duration (from 1 year to 10 years). Laboratory methods were used to determine the level of specific antibodies to diphtheria using immunoenzyme assay. The most negative influence of DM1 on diphtheria antibodies level was noted in children with primarily revealed disease with duration < 1 year. This requires the changes to the choice of immunization tactics in children and teenagers with DM1 with the consideration of the clinical parameters of the disease namely possibility of planned vaccinations, in particular to the children with medical contraindications, on the day of scheduled vaccinations. The obtained findings suggest that DM1 negatively influenced active artificial immunity against diphtheria depending not only the duration of the main disease (DM1) but also its complications.

Key words: duration of type 1 diabetes mellitus, post−vaccination antidiphtheria immunity, children.