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№1' 2013
OBSTETRICS AND GYNECOLOGYInternational Medical Journal, Vol. 19., Iss. 1, 2013, P. 78−81.
The role of thrombophilia in the structure of female infertility etiopathogenesis
Kharkiv National Medical University, Kharkiv, Ukraine
Abstract. Diagnosis and treatment of infertility of married couples is an urgent issue of contemporary gynecology. Introduction of the programs of assisted reproductive technologies to the practice requires investigation of new pathogenetic aspects of their efficacy improvement. Therefore, it is reasonable to reveal possible causes of inefficacy of assisted reproductive technology programs. The amount of homocystein and markers of antiphospholipid syndrome was determined using immunoenzyme method in a group of women with unsuccessful attempts of assisted reproductive technologies. A high level of hyperhomocysteimemia and antiphospholipid antibodies was revealed in the patients with infertility of unknown origin and repeated unsuccessful attempts of assisted reproductive technologies which suggested their negative influence on the results of the programs. The obtained findings allow to choose the tactics of management of this group of women participating in the programs of assisted reproductive technologies.
Key words: hereditary thrombophilia, antiphospholipid syndrome, infertility, in vitro fertilization.