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№4' 2012
ONCOLOGYInternational Medical Journal, Vol. 18., Iss. 4, 2012, P. 82−86.
THE USE OF HORMONE THERAPY AT ATYPICAL ENDOMETRIA HYPERPLASIA IN PATIENTS WITH MICROSATELLITE INSTABILITY AND ESR GENE METHYLATION
Kharkiv National Medical University, Kharkiv, Ukraine
The efficacy of hormone therapy depending on the age, presence of microsatellite instability (MSI) and ESR gene methylation was investigated in 67 patients with atypical endometrial hyperpalsia. It was shown that irrespective of the age, efficacy of standard hormone therapy significantly reduced at diagnosis of MSI, ESR hormone methylation and their combination, which requires timely correction of the therapy or the use of more radical treatment methods.
Key words: atypical endometrial hyperplasia, microsatellite instability, ESR gene.