International Medical Journal, Vol. 17., Iss. 2, 2011, P. 48−51.
INVESTIGATION OF INFLUENCE OF GST GENE METHYLATION ON THE PROGNOSIS OF OVARIAN CANCER COURSE
Kharkiv Medical Academy of Post−graduate Education, Kharkiv, Ukraine
The presence of GST gene methylation and amount of tumor necrosis factor−α in the blood serum as well as morphological properties of tumors in patients with stage I−IV ovarian cancer (T1C−3CN0−1M 0−1) were investigated. It was determined that in patients with moderately differentiated qualitative parameters of the tumor, proliferative activity can be used to predict the remission duration. GST gene methylation is more frequently diagnosed in patients with ovarian cancer with worse prognosis of the disease course.
Key words: ovarian cancer, GST gene, methylation, morphology.