International Medical Journal, Vol. 25., Iss. 4, 2019, P. 59−62.
DIRECT RESULTS OF SURGICAL TREATMENT OF THREE-NEGATIVE BREAST CANCER
Kharkiv Medical Academy of Postgraduate Education
State Institution "SP Grigoriev Institute for Medical Radiology of the National Academy of Medical Sciences of Ukraine", Kharkiv
Molekula Pre−Tumor Medical Center, Kharkiv, Ukraine
Three−negative breast cancer is characterized by aggressive clinical course, early metastasis and poor prognosis, leading to more active oncosurgical tactics and systemic treatment. Due to the aggressive clinical course of this oncopathology with increasing risk of locoregional and distant metastases, the most common surgical treatment tactics are modified variants of radical mastectomy with wide dissection of lymph nodes in areas of potential metastasis. Radicalism of the operation is the cause of the increase in the incidence of wound and lymphoenosis, the development of which depends on many factors, the determination of which is important for the development of methods of prevention of complications. In recent years, in the early stages of the disease, a radical breast resection after a course of adjuvant radiotherapy has been considered as an alternative. To study the immediate post−surgery results of three−negative breast cancer, depending on the initial clinical and pathological parameters and features of therapeutic tactics, a study was conducted in which 66 patients participated. Patients underwent radical mastectomy and breast resection, as well as lymph node dissection. Nine patients underwent aloplastic reconstruction. The results of the analysis showed that most often after radical surgeries, irrespective of their volume, there are lymphovenous complications, the development of which is affected by an increase in body mass index and lesions of lymph nodes. Aloplastic breast reconstruction contributes to a reduced incidence of lymphoid complications, and neoadjuvant chemotherapy is associated with an increased incidence of wound complications. These factors should be considered when planning the surgery protocols of patients with three negative breast cancer.
Key words: three−negative breast cancer, surgical treatment, postoperative complications, risk factors.
1. Byuleten nacionalnogo kancer−reyestru Ukrayini.− K., 2018.− № 19.− URL: http://www.ncru.inf.ua/ publications
2. Ghoncheh M. Incidence and Mortality and Epidemiology of Breast Cancer in the World / M. Ghoncheh, Z. Pournamdar, H. Salehiniya // Asian Pac. J. Cancer. Prev.− 2016.− № 7 (S3).− P. 43−46.− URL: http://journal. waocp.org/article_33891_c5b660f5c0b728516cb7aefb52 1dfae0.pdfM https://doi.org/10.7314/apjcp.2016.17.s3.43
3. Ragim−zade S. E. Rak molochnoj zhelezy: epidemiologiya, faktory riska, patogenez, diagnostika, prognoz / S. E. Ragim−zade // Mizhnarodnij medichnij zhurn.− 2017.− № 2.− S. 60−64.
4. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow−up / E. Senkus, S. Kyriakides, S. Ohno [et al.] // Annals of Oncology.− 2015.− № 26 (Suppl. 5).− v8−v30.− doi: 10.1093/annonc/mdv298
5. Gene expression profiling for diagnosis of triple−negative breast cancer: a multicenter, retrospective cohort study/ Q. Wang, M. Xu, Y. Sun [et al.] // Front Oncol.− 2019.− № 7 (9).− P. 354.− doi: 10.3389/fonc.2019.00354
6. Triple negative breast cancer: 10−year survival update of the applied treatment strategy in Kuwait / S. Fayaz, G. A. Demian, M. El−Sherify [et al.] // Gulf. J. Oncolog.− 2019.− № 1 (29).− P. 53−59.− PMID: 30957764 https://doi.org/10.1093/annonc/mdx364.010
7. Sharma P. Biology and management of patients with triple−negative breast cancer / P. Sharma // Oncologist.− 2016.− № 21 (9).− P. 1050−1062.− doi: 10.1634/theoncologist.2016−0067
8. Kumar P. An overview of triple−negative breast cancer / P. Kumar, R. Aggarwal // Arch. Gynecol. Obstet.− 2016.− № 293 (2).− P. 247−269.− doi: 10.1007/s00404−015−3859−y
9. The different outcomes between breast−conserving surgery and mastectomy in triple−negative breast cancer: a population−based study from the SEER 18 database / Q. X. Chen, X. X. Wang, P. Y. Lin [et al.] // Oncotarget.− 2017.− № 17; 8 (3).− P. 4773−4780.− doi: 10.18632/oncotarget.13976
10. Trends of mastectomy and breast−conserving surgery and related factors in female breast cancer patients treated at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, 2009−2017: A retrospective cohort study / Z. K. Al−Gaithy, B. E. Yaghmoor, M. I. Koumu [et al.] // Ann Med. Surg. (Lond.).− 2019.− № 2 (41).− P. 47−52.− doi: 10.1016/j.amsu.2019.03.012
11. Surgical management of breast cancer in China: A 15−year single−center retrospective study of 18,502 patients / N. S. Huang, M. Y. Liu, J. J. Chen [et al.] // Medicine (Baltimore).− 2016.− № 95 (45).− e4201.− doi: 10.1097/MD.0000000000004201
12. Axillary lymph node dissection for breast cancer: efficacy and complication in developing countries / M. O. Abass, M. D. A. Gismalla, A. A. Alsheikh [et al.] // J. Glob. Oncol.− 2018.− № 4.− P. 1−8.− doi: 10.1200/JGO.18.00080
13. Complications related to breast reconstruction after mastectomy using multiple surgical techniques − a national and international comparative analysis / S. A. Marinescu, C. G. Bejinariu, E. Sapte [et al.] // Rom. J. Morphol. Embryol.− 2019.− № 60 (1).− P. 87−93.
14. Wound healing and postsurgical complications in breast cancer surgery: a comparison between PEAK PlasmaBlade and conventional electrosurgery − a preliminary report of a case series / C. Chiappa, A. Fachinetti, C. Boeri // Ann. Surg. Treat Res.− 2018.− № 95 (3).− P. 129−134.− doi: 10.4174/astr.2018.95.3.129