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№1' 2019

THERAPY

International Medical Journal, Vol. 25., Iss. 1, 2019, P. 16−18.

FUNCTIONAL STATE OF METABOLIC SYNDROME MARKERS IN TRAUMATIC DISEASE IN PATIENTS WITH INCREASED BODY MASS INDEX

Kharkiv National Medical University, Ukraine

Among the metabolic responses to trauma a central position is occupied by the changes in carbohydrate metabolism, being an extremely negative factor in the course of traumatic disease on the background of insulin resistance in the patients with an increased body mass index. By means of multivariate analysis, there was studied the dynamics of nine leading metabolic syndrome indices, calculated on the basis of 1,344 assay sheets in 224 patients with an increased body mass index during polytrauma, which characterized this functional system within the intervals from one day to one year from the moment of injury occurrence. Integral indices were determined and the state of metabolic syndrome indices in a whole were mathematically modelled, a comparative analysis of those allowed to reveal both general patterns and certain features, characteristic for these patients depending on the body mass index at the time of polytrauma occurrence. The analysis of metabolic status in the patients with an increased body mass index during a polytrauma showed the changes depending on the terms of examination and initial counts of body mass index. By mathematical modeling, the manifested deviation in integral index was found if compared with the control both in the early period and in distant terms (one year from the moment of polytrauma occurrence) for all the patients examined. The significant role of metabolic disorders in the pathogenesis of trauma diseases in the patients with elevated body mass index during polytrauma was emphasized, that was a prerequisite for prescribing the proper therapy.

Key words: metabolic syndrome, increased body mass index, polytrauma, traumatic disease, systemic multivariate analysis.