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№4' 2018

DERMATOVENEREOLOGY

International Medical Journal, Vol. 24., Iss. 4, 2018, P. 76−80.


VITAMIN D AND SKIN PATHOLOGY


Bolotna L. A., Sarian O. I., Lysenko K. I.

Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

In recent years, information has been obtained on the role of vitamin D in the mechanism of development and treatment of many diseases; its participation in many biological processes (modulation of cell growth, neuromuscular conductivity, immunity and inflammation, angiogenesis) has been shown. Vitamin D is a unique substance that, under certain conditions, acts as a hormone. Vitamin D deficiency increases the risk of autoimmune and atopic diseases, tumors, cardiovascular, infectious diseases, etc. Vitamin D is involved in the regulation of the proliferation and differentiation of cells of all organs and tissues, including immunocompetent cells, skin cells. It directly initiates a congenital immune response, modulates the proliferation of T−lymphocytes, inhibits the development of Th17 lymphocytes, slows B−cell differentiation, inhibits Th1−associated production and stimulates Th2−associated cytokines, etc. filaggrin, participates in the formation of the stratum corneum, while suppressing the hyperproliferation of keratinocytes, stimulates the formation of antimicrobial peptides, has a photoprotective effect. The role of vitamin D disorders in the pathogenesis of skin diseases: eczematous, autoimmune, bullous, and so on is discussed. Vitamin D reduces susceptibility to infection in patients and controls the local inflammatory immune response. Detection of the anti−inflammatory and immunosuppressive activity of vitamin D opens up new possibilities for the therapeutic use of this substance and its analogues in skin diseases.

Key words: vitamin D, deficiency/insufficiency, pathogenesis, skin, chronic dermatoses.


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