International Medical Journal, Vol. 23., Iss. 3, 2017, P. 27−30.
SORTYLIN INFLUENCE ON THE INDICATORS OF CARBOHYDRATE METABOLISM AT COMBINATION OF CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS
Kharkiv National Medical University, Ukraine
Coronary artery disease and diabetes mellitus are the most common comorbid pathologies in the structure of cardiovascular mortality. Recently, many researchers have paid great attention to the search for new markers of cardiovascular risk diagnosis and its relationship with the indices of carbohydrate metabolism in patients with combined pathology. One of them is sortilin, the level of which is associated with cholesterol metabolism, secretion of low density lipoproteins cholesterol and development of vascular lesions. To confirm the role of sortilin as a marker, a comprehensive examination of patients with comorbid pathology (coronary artery disease and type 2 diabetes mellitus) was performed. The patients were performed general clinical and instrumental examinations; the obtained data were compared. The results of the study prove the association of sortilin with progression of carbohydrate metabolism disorders in the examined patients. It was determined that sortilin level was higher in the presence of type 2 diabetes mellitus, and the course of coronary artery disease was accompanied by an increase in the degree of insulin resistance, hyperinsulinemia, hyperglycemia. The obtained data should be taken into account in the diagnosis of cardiovascular risk in patients with comorbid pathology.
Key words: type 2 diabetes mellitus, coronary artery disease, sortilin, insulin, NOMA index.