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№3' 2017

ENDOCRINOLOGY

International Medical Journal, Vol. 23., Iss. 3, 2017, P. 84−87.


INTERMARRIAGE AND SEX-AGE STRUCTURE IN PATIENTS WITH HYPERTHYROIDISM


Rustamov N. M., Rasulov E. M.

Central Hospital of Seamen, Baku
A. Aliyev Advanced Training Institute for Doctors, Baku, Republic of Azebarjan

Diffuse toxic goiter is one of the most common autoimmune diseases of the endocrine system accounting for 80 % of all cases of thyrotoxicosis. The incidence peak is observed at the age of 30ЃE0 years, women suffer five times more often than men. Diffuse toxic goiter is a hereditary disease; 70 % of patients have one or two relatives with thyroid disorders. To study the frequency and types of intermarriage among the population of Republic of Azerbaijan, a study of more than 2,600 patients with hyperthyroidism was conducted. All of them were treated in the Central Hospital of Seamen (Baku) in 2009ЃE017. Each patient underwent ultrasound examination of the thyroid gland, scan with technetium−99. The sex and age structure of patients with hyperthyroidism was compiled, taking into account the bimodal age distribution. In women born in 1944ЃE970, the peak incidence falls on birth dates within the period of 1958ЃE961; in women born in 1973ЃE997, the peak incidence rate was observed in 1982ЃE985. The surveyed included girls born in 2000ЃE017. Hyperthyroidism in men was most common in the age group born between 1949 and 1991. The lowest number of patients occurred at the dates of birth in 1967ЃE970. The types of intermarriages included those between the cousins, second cousins, uncle and niece, third cousins. The coefficient of inbreeding in patients was 4.2 times higher in comparison with that in the group of healthy persons participating in the study, which indicates the influence of intermarriages on the incidence of hyperthyroidism in the offspring

Key words: hyperthyroidism, intermarriages, inbreeding, sex−age structure.


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