International Medical Journal, Vol. 21., Iss. 3, 2015, P. 26−31.
HEMODYNAMIC, MORPHOLOGICAL AND FUNCTIONAL FEATURES OF ISCHEMIC STROKE AT ATHEROSCLEROTIC PLAQUES OF CEREBRAL ARTERIES
M. Gorky Donetsk National Medical University, Ukraine
The aim of the study was evaluation the hemodynamic parameters and morphological features of the atherosclerotic lesions of cerebral arteries at ischemic stroke and comparison the results obtained in patients with abnormalities of the cerebral arteries. Hemodynamic, morphological data of 117 patients (a mean age 61.3±1.7 years), with cerebral ischemic stroke in the acute period, were analyzed. All patients were divided into two groups: group 1 −− cerebral atherosclerosis and abnormal cerebral arteries; group 2 −− anomalies of cerebral arteries without cerebral atherosclerosis. All participants were investigated by neurological, laboratory and instrumental methods. Hemodynamic disorders (hyperperfusion, hyproperfusion) were found out. As a result of a comprehensive investigation of patients with cerebral ischemic stroke in atherosclerotic lesions and abnormalities of cerebral arteries, especially according to Doppler's ultrasound of the neck vessels, a combination of atherosclerotic lesions and abnormalities of cerebral arteries is leading to development of severe hyperperfusion in areas of atherosclerotic stenotic lesion and angulation, twisting of cerebral arteries. Hypoperfusion of cerebral arteries in patients were diagnosed with a combination of atherosclerotic plaque more than 80−100 % and pathological twisting of the ICA on the both sides. Due to this fact the clinical features of stroke in patients with atherosclerotic lesions of cerebral arteries were characterized by more severe clinical neurological symptomatic than patients with only abnormalities of the cerebral arteries. Thus, severity and variability of hemodynamic characteristics of patients with cerebral ischemic stroke depend on the size of the atherosclerotic plaque and type of anomalies of cerebral arteries.
Key words: ischemic stroke, cerebral arteriosclerosis, cerebral artery anomalies.