International Medical Journal, Vol. 20., Iss. 3, 2014, P. 6−11.
Clinical activity risk factors and long-term prognosis of relapsing-remitting multiple sclerosis
Kiev City Center of Multiple Sclerosis, Ukraine
Bogomolets National Medical University, Kyiv, Ukraine
Relapsing−remitting multiple sclerosis is diagnosed in approximately 85 % of patients in the form of disorders of functional organism systems and remissions. The disease activity is determined by the frequency of exacerbations and disability progress rate. With this purpose we analyzed the findings of 9−year observation of 145 patients. The degree of neurological signs was assessed using EDSS. The patients were investigated using neuroimaging methods (MRI, MRS). Main correlations between clinical and neuroimaging features were shown. Increased lactate level in demyelination foci correlated strongly with exacerbation frequency. The number of T1 foci at the disease onset is an unfavorable prognostic sign. The size of the foci, reduction of NAA/Cr, Cho/Cr indices are prognostically significant for determining the terms of exacerbation development using Kaplan−Meyer method.
Key words: relapsing−remitting multiple sclerosis, disease activity, disability progression, foci.