International Medical Journal, Vol. 20., Iss. 2, 2014, P. 96−100.
CLINICAL DIAGNOSTIC CHARACTERISTICS OF CHRONIC HEPATITIS C IN MEDICAL PROFESSIONALS
Kharkiv Medical Academy for Postgraduate Education
Medical professionals are susceptible to infectious diseases, namely hemocontact hepatitis, due to their professional activity. To establish clinical laboratory and diagnostic peculiarities of chronic viral hepatitis C in medical professionals we compared two age and sex matched groups of patients: 112 health professionals and 112 residents of Kharkiv aged 18−72. Verification of the diagnosis was based on detection of viral RNA, its genotypes, anti−HCVcore/NS3,4,5, and anti −HCV Ig classes G/M in the blood. Analysis of the findings shows that hepatitis C in health professional is registered in the prime of their working activities (30−60 years of age) already in the chronic stage of the disease with signs of hepatic fibrosis. This disease is predominantly registered in health professionals who are directly connected with the blood of the patients, mostly nurses. The course of chronic hepatitis C in health professionals is frequently accompanied by constant or periodic exacerbations with intoxication, cytolytic and mesenchymal inflammatory G/M syndrome, significant morphological liver damage and decrease in its functional capacity. One of the causes for late diagnosis and more severe course of chronic hepatitis C in health professionals is a careless attitude towards their health, as evidenced by their low adherence to testing. The findings of the research can promote improvement of hepatitis C diagnosis in health professionals.
Key words: сhronic hepatitis C, medical professionals, clinical diagnostic indicators.