International Medical Journal, Vol. 20., Iss. 2, 2014, P. 80−86.
ANALYSIS OF THE EFFICACY OF COMBINATION TREATMENT OF OVARIAN CANCER PATIENTS WITH NEOADJUVANT CHEMOTHERAPY
S.P. Grigoriev Institute for Medical Radiology of NAMS of Ukraine, Kharkiv
Ovarian cancer ranks third among oncogynecological diseases and is the leading cause of death among cancer patients. Combination treatment (surgery and chemotherapy) is considered to be the main method of treatment. One of the directions of its efficacy improvement is development of new regimens of chemotherapy and improvement of the techniques of chemotherapy administration. In order to increase the effectiveness of combined treatment of patients with stage III−IV ovarian cancer the results of the treatment were compared with those of the patients treated with traditional methods. Median and mean relapse−free survival were the criteria of assessment depending on the disease stage and the tumor histology. The findings of the research demonstrated that 3−4 cycles of neoadjuvant therapy promoted transition of advanced tumors to the operable ones with the increase of the volume of optimal surgery and reduction of the residual tumors. The use of this method helped to reduce the frequency of tumor recurrence and increased the period of remission in the first two years, compared with patients who received surgery at the first stage, but under the observation of up to 60 months the difference between the first and the control group disappeared.
Key words: ovarian cancer, combination treatment, neoadjuvant chemotherapy.