International Medical Journal, Vol. 19., Iss. 3, 2013, P. 22−29.
SOME MOLECULAR MECHANISMS OF ISCHEMIC STROKE DEVELOPMENT
Tashkent Medical Academy, Tashkent Pediatric Medical Institute, Republic of Uzbekistan
Abstract. The purpose of the study was to investigate the role of nitrous oxide and cholinergic system in the pathogenesis of ischemic stroke. The findings of clinical biochemical investigation at various subtypes and degree of ischemic stroke showed that an important role in its pathogenesis was played by dysfunction of the vascular endothelium, manifesting by reduction of endothelial nitrous oxide and deficiency of cholinergic neuromediation represented by reduction in the level of acetylcholine esterase in the blood serum in the most acute and acute periods of the disease, especially against a background of arterial hypertension and cardiac pathology. Based on the available literature and the original findings the author suggested a scheme of pathobiochemical cascade of ischemic stroke allowing to expand the ideas about the pathogenesis, neurochemical nature of ischemic stroke as well as to develop new directions in diagnosis and more effective treatment.
Key words: ischemic stroke, pathogenesis, nitrous oxide, cholinergic neuromediation, pathobiochemical cascade.