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№2' 2013

THERAPY

International Medical Journal, Vol. 19., Iss. 2, 2013, P. 43−47.

PROGESTERONE AND ITS INFLUENCE ON THE CARDIOVASCULAR SYSTEM IN WOMEN IN EARLY POSTMENOPAUSAL PERIOD

SI "Institute of Therapy named after L.T. Malaya of NAMS of Ukraine", Kharkiv, Ukraine

Abstract. The purpose of the work was to investigate the influence of progesterone level on the parameters of arterial pressure, ejection fraction, electrocardiographic index of myocardial damage and severity of menopause signs in women in early postmenopause. The investigation was done on 91 patients. Follicle stimulating hormone and inhibin B in the blood serum were determined by immonoenzyme method to diagnose menopause. Severity of menopause signs was assessed using Kupperman H. menopausal index. Myocardium state was assessed with electrocardiographic index of myocardial damage. The study demonstrated that healthy women in the period of early physiological menopause do not demonstrate association between the level of progesterone and electrocardiographic index of myocardium damage as well as ejection fraction of the left ventricle but these parameters depended on high density cholesterol lipoproteins, follicle stimulating hormone, heart rate, apolipoptotein B level and menopause signs.

Key words: climax, menopause, progesterone, cardiovascular system.