International Medical Journal, Vol. 18., Iss. 2, 2012, P. 32−36.
CLINICAL SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH RELAPSING OBSTRUCTIVE BRONCHITIS AND BRONCHIAL ASTHMA
Kharkiv National Medical University, Kharkiv, Ukraine
The state of endothelial function was investigated by the activity of blood serum endothein−1 and nitric oxide metabolites in 147 children with relapsing obstructive bronchitis and bronchial asthma. The presence of endothelial dysfunction more pronounced in patients with exacerbations, which manifested as vasoconstriction, increased mean pressure in the pulmonary artery, endothelin−1 level and nitrates against a background of reduced nitrites level, was established. The changes in the levels of endothelium−dependent factors depending on the stage of the disease and its severity were revealed.
Key words: endothelial dysfunction, relapsing obstructive bronchitis, bronchial asthma, children.