EFFECTIVENESS OF ANTIHYPERTENSIVE THERAPY IN COMORBIDITY OF ARTERIAL HYPERTENSION AND OBESITY DEPENDING ON PHYSICAL ACTIVITY
Sumy State University
Kharkiv Medical Academy of Postgraduate Education
V. N. Karazin Kharkiv National University, Ukraine
In order to assess the effectiveness of antihypertensive therapy in comorbidity of hypertension and obesity, depending on physical activity of patients, a study was performed in 200 persons, They were prescribed with a diet therapy as non−drug treatment and an increased physical activity was recommended. The patients received a combination of an angiotensin converting enzyme inhibitor and a calcium antagonist. Primary blood pressure levels of the patients were evaluated 3 months after initiation of treatment: only 102 among 200 had reached the target levels in dual antihypertensive therapy, and the rest required an additional antihypertensive medication. As a result of the study, it has been found that physical activity positively affected the dynamics of cardiovascular remodeling, anthropometric and biochemical data as part of a comprehensive 6−month treatment of hypertensive patients with obesity (including dual antihypertensive therapy). With the similar drug treatment the patients with sufficient physical activity differed from those with low physical activity by the significantly lower body mass index, better dynamics of cardiovascular remodeling, higher levels of antiatherogenic lipoprotein, high inflammatory disease, and less pronounced adipokine imbalance.
Key words: arterial hypertension, obesity, antihypertensive therapy, physical activity.