International Medical Journal, Vol. 21., Iss. 3, 2015, P. 5−8.
THE ROLE OF MICROELEMENTOSIS IN PATHOGENESIS OF RESPIRATORY DISORDERS AT CHRONIC RHEUMATIC HEART DISEASE
M. Gorky Donetsk National Medical University, Ukraine
The purpose of the work was to evaluate the clinical pathogenic significance of blood cardioprotective (Cu, Zn) and cardiotoxic (Cd, Co, Pb) trace elements (TE) in patients with chronic rheumatic heart disease (CRHD) depending on the changes in ventilating, moisture production, diffusing, conditioning and surfactant lung functions. The study involved 105 patients with CRHD (28 % men and 72 % women) aged from 15 to 60. Blood serum TE content was studied by atomic absorption spectrometry with electrographite atomizer (SolAAr−Mk2−MOZe, UK). Echocardiography, spirography, body pneumography, pneumothermocalorimetry, respiratory moisture production rate and physical−chemical properties of expirates were performed. Significant Cd increase in blood by 9 % with decrease in Cu by 10 %, Zn by 5 % and Pb by 54 % were observed in CRHD that was recorded in 6 %, 22 %, 25 % and 54 % of the patients respectively. Microelementosis participates in pathogenic formation of CRHD that determines formation of pulmonary artery pressure (Co) and pulmonary vascular resistance (Cu, Pb). Development of pulmonary hypertension, enlargement of the right heart ventricle, disorders of moisture production, diffusion, conditioning and surfactantgenous lung function were associated with imbalance of Cd, Co, Cu, Pb and Zn in the blood, the parameters of which change in case of pressure increase in pulmonary circulation. The end−diastolic increase of the right heart ventricle size was accompanied by inhibition of Cu and Zn concentrations at increase of Co content. In the pathogenesis of various respiratory dysfunctions at CRHD the role of each TE has its own characteristics; the levels of cupremia and zinkemia have prognostic significance in relation to progression of pulmonary hypertension and changes of diffusing lungs capacity.
Key words: rheumatism, heart, defects, lungs, trace elements.