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№3' 2021

THERAPY

International Medical Journal, Vol. 27., Iss. 3, 2021, P. 15−18.

DOI (https://doi.org/10.37436/2308-5274-2021-3-3)

STATE OF LIPID PEROXIDATION IN PATIENTS WITH DIABETES MELLITUS AND ERECTILE DYSFUNCTION

Avrasiya Hospital, Baku, Azerbaijan

Diabetes mellitus is the most common cause of men erectile dysfunction, which is observed in everyday medical practice. Diabetic erectile dysfunction occurs as a result of a combination of neurogenic and vascular disorders. Important mechanisms of microcirculation disorders include those of lipid peroxidation of biomembranes. Normally, the lipid peroxidation is controlled by antioxidant regulatory systems, among which the key role belongs to the intracellular antioxidant system. For a comparative study of lipid peroxidation in the patients with Diabetes mellitus and erectile dysfunction, 59 people were examined. The diagnosis was determined on the basis of anamnesis, results of physical examination, test with intracavernous injection, echo−Doppler penile assessment, cavernosography−cavernosometry and the penile night test. Cavernous and peripheral venous blood was sampled from each patient, lipid peroxide levels were determined, and overall antioxidant status was established. Analysis of the results revealed a slight difference between nitric oxide levels for venous and cavernous parameters in patients with diabetes. The strong correlation between venous and cavernous values of levels of biochemical markers indicates systemic transformations in the body. Based on high levels of lipoprotein−α and malonic dialdehyde and low levels of nitric oxide for peripheral venous blood, a conclusion was made about the correlation with the severity of erectile dysfunction, which is determined during duplex ultrasound investigation. The need for future research on various biochemical markers among a larger population of men with this associated pathology is emphasized.

Key words: etiology, erectile dysfunction, diabetes mellitus, lipid peroxidation, diagnosis.

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