Previous

CURRENT ISSUE

№1' 2021

MEDICO-SOCIAL PROBLEMS

International Medical Journal, Vol. 27., Iss. 1, 2021, P. 92−100.


DOI (https://doi.org/10.37436/2308-5274-2021-1-17)

SONOGRAPHIC MARKERS OF ASSOCIATION OF FOLATE CYCLE POLYMORPHIC GENES AND EPIGENETIC FACTORS


Alieva T. D.

Kharkiv National Medical University, Ukrainian Institute of Clinical Genetics, Kharkiv, Ukraine

Reproductive losses in Ukraine are about twice the European average, but have the same causes: miscarriage, abortion, malformations, parental infertility, death of women of childbearing age and children under six days of age. The study focuses on genetically determined reproductive losses associated with folate cycle polymorphism, some other polymorphisms, and epigenetic factors that increase the risk of adverse pregnancy outcomes. Methods of systematic and demographic analysis studied the indices of medical and statistical observation of the population of the Kharkiv region within the period of 2008−2018 with an emphasis on the results of biochemical, molecular genetic and sonographic examinations of pregnant women. Data on the number of examined pregnant women were analyzed using ultrasonographic and biochemical studies at the level of alpha−fetoprotein, chorionic gonadotropin and free estriol in the framework of selective screening programs for pregnant women. Statistical data on the number of fetuses and newborns who died during the first − sixth day after birth, with a distribution on the basis of full−term have been studied. The data are compared with similar national indices. The directions of reducing the reproductive losses are offered, including complex inspection of pregnant women with use of ultrasonography, biochemical and molecular−genetic methods of diagnostics of genetic diseases and defects of fetus development. Among the epigenetic factors we have identified obesity and old age of pregnant women, among the types of abortions we did medical abortions associated with stillborn pregnancies, as well as miscarriages. The findings of the study can be used to minimize the effects of risk factors for reproductive loss in the activity of general practitioners.

Key words: polymorphism of folate cycle genes, reproductive losses, miscarriage, congenital malformations of fetus, ultrasonography.


REFERENCES


1. Association between adverse pregnancy outcome and imbalance in angiogenic regulators and oxidative stress biomarkers in gestational hypertension and preeclampsia / C. A. Turpin et al. // BMC Pregnancy Childbirth. 2015. № 15. P. 189. https://doi.org/10.1186/s12884−015−0624−y

2. Inflammation in Complicated Pregnancy and Its Outcome / R. R. Kalagiri et al. // Am. J. Perinatol. 2016. Vol. 33, № 14. P. 1337−1356.

3. Risk of recurrent stillbirth: systematic review and meta−analysis / K. Lamont et al. // BMJ. 2015. № 350. P. h3080. https://doi.org/10.1136/bmj.h3080

4. Sugiura−Ogasawara M. Recurrent pregnancy loss and obesity // Best. Pract Res. Clin. Obstet. Gynaecol. 2015. Vol. 29, № 4. P. 489−497. https://doi.org/10.1016/j.bpobgyn.2014.12.001

5. Alієva T. D. K. Zasadi zapobіgannya rizikam rannіkh reproduktivnikh vtrat v kontekstі olіgonukleotidnogo polіmorfіzmu genіv folatnogo tsiklu // Vіsn. Kharkіvs'kogo regіonal'nogo іnstitutu problem gromads'koї okhoroni zdorov'ya. 2019. T. 89, № 3. S. 4−23. doi: 10.5281/zenodo.3582796

6. Demidov V. N., Stygar A. M., Bakharev V. A. Ul'trazvukovaya i immunofermentnaya diagnostika porokov razvitiya perednei bryushnoi stenki i diafragmy ploda // Akusherstvo i ginekologiya. 2008. № 7. S. 31−34.

7. Art'omenko V. V. Porіvnyal'nі aspekti prenatal'noї dіagnostiki vrodzhenikh vad rozvitku і khromosomnikh anomalіi z vikoristannyam ekhografії ta bіokhіmіchnogo skrinіngu // Odes'kii medichnii zhurn. 2014. T. 146, № 6. S. 35−39.

8. Statistichnі danі shchodo zakhvoryuvanostі ukraїntsіv ta medichnoї dopomogi za 1993−2018 roki // Tsentr medichnoї statistiki MOZ Ukraїni. URL: http://medstat.gov.ua/ukr/statdan.html

9. The association between gestational weight gain and risk of stillbirth: a populationbased cohort study / R. Yao et al. // Ann. Epidemiol. 2017. Vol. 27, № 10. P. 638−644.

10. Kaser D. The status of genetic screening in recurrent pregnancy loss // Obstet. Gynecol. Clin. North Am. 2018. Vol. 45, № 1. P. 143−154.

11. Correlation between chromosomal distribution and embryonic findings on ultrasound in early pregnancy loss after IVF−embryo transfer / Y. Ouyang et al. // Hum. Reprod. 2016. Vol. 31, № 10. P. 2212−2218. https://doi.org/10.1093/humrep/dew201

12. Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges / T. Sahoo et al. // Genet. Med. 2017. Vol. 19, № 1. P. 83−89.

13. Nash opyt diagnostiki vrozhdennykh porokov razvitiya pri pervom ul'trazvukovom skriningovom issledovanii / E. V. Orekhova i dr. // Obmen opytom. 2011. T. 10, № 4. S. 305−308.

14. Mel'nikova V. Yu., Dodkhoeva M. F. Sovremennye metody prenatal'noi diagnostiki i profilaktiki vrozhdennykh porokov razvitiya tsentral'noi nervnoi sistemy ploda (Obzor literatury) // Vestn. Avitsenny. 2016. № 1. S. 109−115.

15. Maksimovs'ka V. M. Prenatal'ne ta postnatal'ne dіagnostuvannya sindromu Dauna // Korektsіina ta sotsіal'na pedagogіka і psikhologіya. 2012. № 2. S. 160−167.

16. Rakhkhal Z. N. Kliniko−geneticheskoe znachenie mnogovodiya pri vrozhdennykh porokakh razvitiya ploda: avtoref. ... dis. kand. med. nauk: 14.01.01. M., 2005. 24 s.

17. Rossen L. M., Ahrens K. A., Branum A. M. Trends in risk of pregnancy loss among US women, 1990−2011 // Paediatr. Perinat. Epidemiol. 2018. Vol. 32, № 10. P. 19−29. https://doi.org/10.1111/ppe.12417

18. Alieva T. D. Izuchenie roli assotsiatsii polimorfizmov genov folatnogo tsikla i khromosomnogo polimorfizma u materi v formirovanii reproduktivnykh poter' // Vestn. problem biologii i meditsiny. 2013. T. 1 (104), № 4. S. 78−84.

19. Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss − A Systematic Review and Meta−Analysis / M. Zhang et al. // PLoS One. 2017. Vol. 12, № 1. P. e0169891. https://doi.org/10.1371/journal.pone.0169891

20. Association between vascular endothelial growth factor polymorphism and recurrent pregnancy loss: A systematic review and meta−analysis / Y. Sun et al. // Eur. J. Obstet. Gynecol. Reprod Biol. 2017. № 211. P. 169−176.

21. Novel genes and mutations in patients affected by recurrent pregnancy loss / P. Quintero−Ronderos et al. // PLoS One. 2017. Vol. 12, № 10. P. e0186149. https://doi.org/10.1371/journal.pone.0186149

22. Adverse pregnancy outcomes and periodontitis: A systematic review and metaanalysis exploring potential association / S. Corbella et al. // Quintessence Int. 2016. Vol. 47, № 3. P. 193−204.

23. Jahanfar S., Lim K., Ovideo−Joekes E. Birth weight discordance and adverse perinatal outcomes // J. Perinat. Med. 2017. Vol. 45, № 5. P. 603−611. https://doi.org/10.1515/jpm−2016−0089

24. Associations of pre−pregnancy obesity with adverse pregnancy outcomes and the optimal gestational weight gain in Japanese women / R. Toma et al. // Clin. Exp. Obstet. Gynecol. 2017. Vol. 44, № 2. P. 190−194.

25. The risk of adverse pregnancy outcomes following nonobstetric surgery during pregnancy: estimates from a retrospective cohort study of 6.5 million pregnancies / V. Balinskaite et al. // Ann. Surg. 2017. Vol. 266, № 2. P. 260−266. https://doi.org/10.1097/sla.0000000000001976

Go on Top