International Medical Journal, Vol. 25., Iss. 2, 2019, P. 9−13.
FUNCTIONAL STATE OF SECRETORY ACTIVITY OF ADIPOSE TISSUE IN TRAUMATIC DISEASE IN PATIENTS WITH INCREASED BODY MASS INDEX
Kharkiv National Medical University, Ukraine
Considering that the majority of those suffering from an increased body mass index with traumatic injuries at the moment of admission to the hospital have a concomitant pathology, it is very important to study the readiness of such patients for a stressful release of systemic inflammatory response markers. By means of system multivariate analysis, as a result of studying the dynamics of seven leading indices (adiponectin, leptin, resistin, interleukin−6 and 8, tumor necrosis factor alpha−2, C−reactive protein), the functional state of markers of the systemic inflammatory response as the products of secretory function of adipose tissue, which were calculated on the basis of 1,344 assay sheets in 224 patients with an increased body mass index during polytrauma, that characterized this functional system in the intervals from one day to one year from the time of damages, the integral indices were determined and mathematical model of the state of fatty tissue biomarkers activity was developed. Mathematical modeling allowed the revealing of an expressed deviation of the integral index compared with the control both at the early period and in the long term, i.e. one year after polytrauma getting for all the patients examined. The leading role of disorders in the system of fatty tissue biomarkers in the pathogenesis of trauma diseases in the patients with an increased body mass index with traumatic injuries was emphasized, which is a prerequisite for prescribing the appropriate therapies.
Key words: systemic multivariate analysis, adipose tissue secretion products, increased body mass index, polytrauma.