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№1' 2018

THERAPY

International Medical Journal, Vol. 24., Iss. 1, 2018, P. 29−32.

INTERLEUKIN-22 AND ANTHROPOMETRICS PARAMETERS RELATIONS IN PATIENTS WITH HYPERTENSION

Kharkiv National Medical University, Ukraine

The purpose of this study was to investigate anthropometric and hemodynamic parameters in patients with essential hypertension, depending on the serum level of interleukin−22 (IL−22). The study involved 81 patients with hypertension who underwent detailed clinical, anthropometric, laboratory and instrumental examination. The diagnosis was verified using the criteria of the European Society of Hypertension (ESH) (2013). Abdominal obesity (AO) was diagnosed in patients with waist circumference over 102 cm for males and 88 cm for females, according to the guidelines of Association of Cardiologists of Ukraine (2012). IL−22 serum level was determined by enzyme immunoassay using Bender Medsystems® Human IL−22 Platinum ELISA kit. All patients were divided into tertiles by IL−22 serum fasting level. The level of IL−22 in the first tertile ranged from 20.23 pg/ml to 27.40 pg/ml; in the second one −− 27.49−31.51 pg/ml; in the third tertile the level of IL−22 was 31.61 −− 54,93 pg/ml. A comparative analysis of hemodynamic parameters (systolic blood pressure (SBP), diastolic blood pressure (DBP), pulsatile blood pressure (PBP)) was performed in patients with hypertension, depending on the level of IL−22, which demonstrated that SBP, DBP and PBP were significantly increased in parallel with an increase in the IL−22 serum level (p < 0.05). It was also found that the higher the level of IL−22 in the blood, the higher were the anthropometric indices such as body mass, body mass index (BMI), waist and hips circumference, waist to hips ratio, p < 0.05. A comparative intertertile analysis showed that the number of patients with AO increased together with an increase in Il−22 serum level. In conclusion, the obtained data, namely, a significant increase in BP values, in relation with an increase in the IL−22 serum level in hypertensive patients, may indicate involvement of the investigated cytokine in the pathogenesis of hypertension. In addition to it, our results suggest in favor of IL−22 significant role in development of obesity.

Key words: hypertension, interleukin−22, anthropometric indices.