International Medical Journal, Vol. 22., Iss. 1, 2016, P. 38−41.
DYNAMICS OF REPARATIVE PROCESSES IN PLANAR SKIN WOUNDS AT LOCAL APPLICATION OF OINTMENTS BASED ON A CONCENTRATE OF CANNED ANTLERS
Russian Research Institute of Reindeer Antlers, Barnaul, Russian Federation
Altai State Medical University, Barnaul, Russian Federation
Wound healing is one of the most ancient, but not aging problems of practical medicine. In recent years, pharmacological agents of animal origin, which are active biological stimulants, have been increasingly applied in clinical practice. The aim of the work was to study the wound healing activity of ointments on the basis of a concentrate of canned deer antlers. To accomplish the objectives an experiment in rabbits was carried out. Each animal was inflicted a planar wound to the skin. Fifteen rabbits were divided into 3 groups depending on the method of local treatment: the controls healed in a natural way; groups 1 and 2 were applied daily ointment made of a concentrate of canned antlers. The effect of drugs on wound healing was assessed using planimetry method with the wound area and percentage of area reduction of the wound surface per day. Statistical processing was performed using Statistica 7.0 software. Two independent groups were compared using Mann−Whitney U−test, three or more using rank analysis of variance with Kruskal−Wallis test followed by pairwise comparisons of groups Mann−Whitney test with Bonferroni correction when assessing the value of p. In the course of the following results: the rate of wound healing in experimental animals is 1.5 times higher than the rate of healing of wounds of the control group. Complete healing of wounds in the first experimental group occurred on average at day 21 in the second experimental group −− 23 e. Complete healing of wounds in the control group, the topical treatment of wounds which are not carried out, came only a 26 day. The following results were obtained: 1) according to the pilot study the ointment has a wound−healing effect, which is evidenced by the dynamics of indicators of wound healing (higher rate of wound area reduction and shortening of wound epithelialization by 3−5 days in the experimental groups; more rapid rejection of scab in the experimental groups of animals); 2) these findings can be used for further study of the possibility of using the concentrate from deer antlers as part of formulations for topical application at treatment of wounds of different origin in humans.
Key words: wound, regeneration, concentrate of canned antlers.