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№4' 2015

OPHTHALMOLOGY

International Medical Journal, Vol. 21., Iss. 4, 2015, P. 69−71.


PROSPECTS OF MESENCHYMAL STROMAL CELLS APPLICATION IN PREVENTION AND THERAPY FOR DIABETIC RETINOPATHY


Demyn Yu. A., Sergienko A. N., Demyna M. Yu.

Kharkiv Medical Academy for Postgraduate Education, Ukraine

Diabetic retinopathy is the most common microvascular complication of diabetes mellitus and a leading cause of vision loss among people of working age, making a complex economic and social problem. In recent years, mesenchymal stromal cells are considered a new direction in regenerative medicine due to their multi−functionality and the ability to paracrine secretion of angiogenic factors, cytokines and immunomodulatory substances. The analysis of the literature suggests that the presence of immunomodulating properties, the ability to self−renewal and differentiation allow to consider mesenchymal stromal cells promising agents for prevention prophylaxis and treatment of diabetic retinopathy. The advantages of their therapeutic application may include the ability to migrate to the site of tissue damage, lower risk of side effects at infusion of allogeneic cells and absence of ethical issues related to the use of human embryonic cells.

Key words: diabetic retinopathy, placental mesenchymal stromal cells, type 2 diabetes mellitus.


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