International Medical Journal, Vol. 19., Iss. 4, 2013, P. 65−68.
VASCULAR ENDOTHELIAL GROWTH FACTOR IN PSORIASIS: PATHOGENETIC AND THERAPEUTIC ASPECTS
Kharkiv Medical Academy of Postgraduate Education
Recent studies have shown that one of the most important parts of the pathogenesis is unbalanced vascularization. Angiogenesis in psoriasis is characterized by the presence of enhanced proliferation of endothelial cells lining the inner surface of the blood vessels. It is known that epidermal keratinocytes in psoriasis patients are the major source of pro−angiogenic factors, interleukin−1, 6 , 8, tumor necrosis factor α, vascular endothelial growth factor (VEGF). VEGF is recognized the key proangiogenic factor responsible for formation of new blood vessels in psoriatic plaques. This factor plays an important role in inflammation initiation, as a factor enhancing vascular permeability. Our studies revealed a significant increase of VEGF content in the serum of patients with common psoriasis. Treatment of psoriasis with topical corticosteroids, drugs of biological therapy has a positive effect on the level of VEGF. The application of anti−VEGF drugs to psoriasis treatment in future is discussed.
Key words: psoriasis, angiogenesis, vascular endothelial growth factor, pathogenesis, therapy.